DSIP
DSIP 10mg: delta sleep-inducing peptide, a nonapeptide (CAS 62568-57-4) isolated in 1977 with an unresolved mechanism. Research use only.
What it is
DSIP, delta sleep-inducing peptide, is a nonapeptide with the sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu (WAGGDASGE). It was isolated in 1977 from the cerebral venous blood of rabbits and named for the delta-wave EEG pattern recorded in rabbits in that first study by Schoenenberger and Monnier. Molecular formula C35H48N10O15, molecular weight 848.8 g/mol, CAS 62568-57-4, PubChem CID 68816.
A 2006 review in the Journal of Neurochemistry notes that no DSIP gene, precursor protein or receptor has been isolated, so its mechanism remains unresolved. An earlier 1984 review summarised DSIP-like immunoreactivity in rat brain and peripheral organs and in the plasma of several mammals. Later work includes a rat focal stroke model (middle cerebral artery occlusion). USA Warehouse Supply lists DSIP 10mg as a lyophilized powder for laboratory research use only, shipped from the U.S..
Storage
- A manufacturer data sheet lists storage of the dry peptide at 0 to 5°C (32 to 41°F) before use.
- The same data sheet advises rehydrating the peptide immediately before use and not refreezing any unused portion.
- DSIP contains tryptophan, which a manufacturer peptide handling guide lists among the residues that need care to avoid oxidation.
Cited research applications
Questions
What is DSIP?
DSIP (delta sleep-inducing peptide) is a nonapeptide, Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu, isolated in 1977 from the cerebral venous blood of rabbits. Schoenenberger and Monnier named it after the delta-wave EEG pattern they recorded when the peptide was infused into the brain ventricles of rabbits. Molecular formula C35H48N10O15, molecular weight 848.8 g/mol, CAS 62568-57-4, PubChem CID 68816.
The name records that first observation, not a settled mechanism. A 2006 review in the Journal of Neurochemistry notes that no DSIP gene, precursor protein or receptor has been isolated. A 1984 review summarised DSIP-like immunoreactivity in rat brain and peripheral organs and in the plasma of several mammals. USA Warehouse Supply lists DSIP 10mg as a lyophilized powder for laboratory research.
Compound identifiers & literature
Public database identifiers and a selection of peer-reviewed publications for DSIP (Delta sleep-inducing peptide), provided so researchers can verify this compound independently. Each entry links to the primary source.
Selected literature
- [1]Kovalzon VM, Strekalova TV (2006). Delta sleep-inducing peptide (DSIP): a still unresolved riddle Journal of Neurochemistry 97(2):303-309.A critical mini-review stating that no DSIP gene, protein or related receptor has been isolated since the peptide's 1977 description from rabbit cerebral venous blood, and characterising the hypothesis of DSIP as a sleep factor as poorly documented. The authors note that significant slow-wave-sleep-promoting activity in rabbits and rats was observed for certain artificial DSIP structural analogues but not for DSIP itself, and propose the existence of a separate DSIP-like peptide to account for reported DSIP-like immunoreactivity.
- [2]Tukhovskaya EA, Ismailova AM, Shaykhutdinova ER, et al. (2021). Delta Sleep-Inducing Peptide Recovers Motor Function in SD Rats after Focal Stroke Molecules 26(17):5173.DSIP was given to Sprague-Dawley rats in a pre-treatment design, beginning about 60 minutes before intraluminal middle cerebral artery occlusion and continuing for seven days after reperfusion, with behavioural assessment on days 1, 3, 7, 14 and 21. The authors reported significant recovery of motor performance on the rotarod in DSIP-treated animals, no significant effect in the ketamine-induced rotation test, and a smaller but statistically non-significant difference in brain infarct volume (20.9 plus or minus 6.9 percent versus 24.1 plus or minus 4.6 percent in vehicle controls). Laser Doppler flowmetry was used intraoperatively to verify occlusion and reperfusion rather than as a longitudinal outcome measure.
- [3]Roy K, Chauhan G, Kumari P, et al. (2018). Phosphorylated delta sleep inducing peptide restores spatial memory and p-CREB expression by improving sleep architecture at high altitude Life Sciences 209:282-290.Phosphorylated DSIP, a modified analogue rather than DSIP itself, was given to Sprague-Dawley rats during chronic hypobaric hypoxia simulating an altitude of 7,620 metres, with non-rapid-eye-movement and rapid-eye-movement sleep architecture, Morris water maze performance and CREB phosphorylation measured. The authors reported changes in sleep architecture and water maze performance relative to untreated hypoxia-exposed animals, and reported that naloxone suppressed these effects, which they interpreted as opioid receptor involvement.
These references are provided for scientific context only. They describe published research on this compound and are not evidence of safety or efficacy, not an endorsement of any use, and not medical advice. This product is supplied for laboratory research use only — not for human or animal consumption.
For Research Use Only. Not for human or animal consumption. This product has not been evaluated by the Food and Drug Administration. Not intended to diagnose, treat, cure, or prevent any disease. DSIP is sold strictly as a research chemical for in-vitro and pre-clinical laboratory investigation only.