NAD+
NAD+, the nicotinamide adenine dinucleotide coenzyme, in a 500mg vial for redox research. Ships from the U.S..
What it is
NAD+ (nicotinamide adenine dinucleotide, oxidized form) is a coenzyme, not a peptide. Reviews describe it as a coenzyme for redox reactions: NAD+ accepts a hydride ion to form its reduced version, NADH. Molecular formula C21H27N7O14P2, molecular weight 663.4 g/mol, CAS 53-84-9, PubChem CID 5892, where the record is titled nadide. USA Warehouse Supply lists the oxidized form, NAD+.
Beyond redox chemistry, NAD+ is a cofactor for non-redox NAD+-dependent enzymes studied in cell and animal models: sirtuins, PARP enzymes and CD38, an NAD+ glycohydrolase. Reviews describe sirtuins and PARPs as competing NAD+-consuming enzymes, PARPs as the largest family of NAD+ consumers in cells, and CD38 as the main NAD+-degrading enzyme in mammalian tissues. NAD+ consumers are found in the nucleus, cytoplasm and mitochondria. USA Warehouse Supply lists NAD+ as a 500mg powder vial for laboratory research use only.
Storage
- A manufacturer data sheet lists solid NAD+ for storage at -20°C (-4°F), with stated stability of 4 years.
- Store as set out in the lyophilized-peptide storage note on the research library page.
Cited research applications
Questions
What is NAD+?
NAD+ (nicotinamide adenine dinucleotide, oxidized form) is a dinucleotide coenzyme, not a peptide: two nucleotides, one carrying nicotinamide and one carrying adenine, joined through their phosphate groups. Molecular formula C21H27N7O14P2, molecular weight 663.4 g/mol, CAS 53-84-9, PubChem CID 5892. Synonyms: nadide, beta-nicotinamide adenine dinucleotide. In cell and animal studies it is the oxidized partner of NADH in redox reactions and the substrate consumed by sirtuins, PARP enzymes and CD38. As a solid it is a white to off-white powder that is hygroscopic and sensitive to light, heat and alkaline conditions; it is stored sealed at -20°C and protected from light, and solutions are prepared fresh in a neutral or slightly acidic buffer and used promptly or frozen in aliquots. USA Warehouse Supply lists NAD+ as a powder vial for laboratory research.
What is the difference between NAD+ and NADH?
NAD+ and NADH are the oxidized and reduced forms of the same coenzyme, nicotinamide adenine dinucleotide. Reviews describe NAD+ as a coenzyme for redox reactions that accepts a hydride ion to form its reduced version, NADH.
Outside redox reactions, NAD+ is a cofactor for non-redox NAD+-dependent enzymes: sirtuins, PARP enzymes and the NAD+ glycohydrolase CD38. Reviews describe sirtuins and PARPs as competing NAD+-consuming enzymes and CD38 as the main NAD+-degrading enzyme in mammalian tissues.
USA Warehouse Supply lists the oxidized form, NAD+ (CAS 53-84-9, PubChem CID 5892), as a 500mg powder vial for laboratory research. Reference supplier data list solid NAD+ for storage at -20°C.
Compound identifiers & literature
Public database identifiers and a selection of peer-reviewed publications for NAD+ (Nicotinamide adenine dinucleotide, oxidized form; INN/USAN "nadide"), provided so researchers can verify this compound independently. Each entry links to the primary source.
Selected literature
- [1]Covarrubias AJ, Perrone R, Grozio A, Verdin E (2021). NAD+ metabolism and its roles in cellular processes during ageing Nature Reviews Molecular Cell Biology.Review of NAD+ biosynthetic and consumption pathways, the enzyme classes that use NAD+ as a cofactor or substrate, and reported changes in tissue NAD+ levels during ageing.
- [2]Gomes AP, Price NL, Ling AJY, et al. (2013). Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging Cell.Measured NAD+ levels and expression of mitochondrially encoded OXPHOS subunits in skeletal muscle of mice aged 6, 22 and 30 months, alongside cultured mouse myoblasts, and examined the effect of SIRT1 deletion on these measures. No human subjects were involved.
These references are provided for scientific context only. They describe published research on this compound and are not evidence of safety or efficacy, not an endorsement of any use, and not medical advice. This product is supplied for laboratory research use only — not for human or animal consumption.
For Research Use Only. Not for human or animal consumption. This product has not been evaluated by the Food and Drug Administration. Not intended to diagnose, treat, cure, or prevent any disease. NAD+ is sold strictly as a research chemical for in-vitro and pre-clinical laboratory investigation only.