Selank

Compound identifiers & literature

Public database identifiers and a selection of peer-reviewed publications for Selank, provided so researchers can verify this compound independently. Each entry links to the primary source.

Selected literature

1. [1]
   Zozulia AA, Neznamov GG, Siuniakov TS, Kost NV, Gabaeva MV, Sokolov OIu, Serebriakova EV, Siranchieva OA, Andriushenko AV, Telesheva ES, Siuniakov SA, Smulevich AB, Miasoedov NF, Seredenin SB (2008). [Efficacy and possible mechanisms of action of a new peptide anxiolytic selank in the therapy of generalized anxiety disorders and neurasthenia] Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova, 108(4):38-48 (Russian).

   In a Russian comparative study of 62 patients diagnosed with generalized anxiety disorder or neurasthenia, 30 received selank and 32 received medazepam, with symptom ratings collected on the Hamilton, Zung and CGI scales and enkephalin-degrading activity measured in blood serum.

   human clinical trialPMID 18454096
2. [2]
   Medvedev VE, Tereshchenko ON, Israelian AIu, Chobanu IK, Kost NV, Sokolov OIu, Miasoedov NF (2014). [A comparison of the anxiolytic effect and tolerability of selank and phenazepam in the treatment of anxiety disorders] Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova, 114:17-22 (Russian).

   A Russian-language comparative study in 60 patients with phobic-anxiety and somatoform disorders in which selank was compared with the benzodiazepine phenazepam, with anxiolytic effect and tolerability assessed during treatment and at follow-up; dosing details are not stated in the English abstract.

   human clinical trialPMID 25176261
3. [3]
   Volkova A, Shadrina M, Kolomin T, Andreeva L, Limborska S, Myasoedov N, Slominsky P (2016). Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission Frontiers in Pharmacology, 7:31.

   Rats were given selank or GABA at 300 ug/kg and expression of 84 neurotransmission-related genes was measured in frontal cortex tissue at 1 hour and 3 hours after administration, with 45 genes altered at 1 hour and 22 at 3 hours.

   rodentPMID 26924987DOI
4. [4]
   Filatova E, Kasian A, Kolomin T, Rybalkina E, Alieva A, Andreeva L, Limborska S, Myasoedov N, Pavlova G, Slominsky P, Shadrina M (2017). GABA, Selank, and Olanzapine Affect the Expression of Genes Involved in GABAergic Neurotransmission in IMR-32 Cells Frontiers in Pharmacology, 8:89.

   Expression of 84 GABAergic-system genes was measured in cultured IMR-32 human neuroblastoma cells exposed to GABA, selank or olanzapine alone and in combination; the authors report no change in the mRNA levels of the genes studied under the effect of selank alone.

   in vitroPMID 28293190DOI
5. [5]
   Kasian A, Kolomin T, Andreeva L, Bondarenko E, Myasoedov N, Slominsky P, Shadrina M (2017). Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictable Chronic Mild Stress Conditions in Rats Behavioural Neurology, 2017:5091027.

   Male Wistar rats were assessed in the elevated plus maze after administration of selank, diazepam, or the two combined, with and without an unpredictable chronic mild stress protocol; the authors report the combination as most effective under stress conditions, while in unstressed animals the treatments initially shifted anxiety indicators in the opposite (anxiogenic) direction.

   rodentPMID 28280289DOI
6. [6]
   Konstantinopolsky MA, Chernyakova IV, Kolik LG (2022). Selank, a Peptide Analog of Tuftsin, Attenuates Aversive Signs of Morphine Withdrawal in Rats Bulletin of Experimental Biology and Medicine, 173(6):730-733.

   Selank at 0.3 mg/kg was tested against diazepam at 2 mg/kg in a naloxone-precipitated morphine withdrawal model in outbred rats, with withdrawal signs and tactile sensitivity thresholds scored.

   rodentPMID 36322304DOI

These references are provided for scientific context only. They describe published research on this compound and are not evidence of safety or efficacy, not an endorsement of any use, and not medical advice. This product is supplied for laboratory research use only — not for human or animal consumption.